Highway Work Zones (HWZs) present a major hazard for road users, construction workers and equipment, and significantly contribute to occurrence of road crashes worldwide. The present study focuses on analysing the current state of safety measures at HWZs in Pakistan. A more direct approach is adopted by comparing safety measures at randomly selected HWZs in Pakistan with well-established safety procedures in Manual on Uniform Traffic Control Devices (MUTCD). HWZ safety measures such as traffic signs, markings, safety measures for pedestrians, workers and construction machinery, police enforcement, speed control measures, provision of advance warning area, buffer spaces, transition areas, and tapers for eight different HWZs were studied and compared with MUTCD standards. The results revealed that majority of the HWZs in Pakistan do not conform to any standard layout especially for safety and speed control measures. An enhanced need for special efforts towards improving safety at HWZs in Pakistan is highlighted.