Nowadays, there are many maintenance projects to mitigate the aging of the US roads and the increase in traffic demand. Despite recent efforts to improve work zone safety, the number and severity of crashes at work zones is still considerably high. The effect of construction zones on traffic safety can be exacerbated by adverse weather conditions, a sudden reduction in visibility may intensify the severity of work zone crashes. There is a lack of studies that strive to gain a good understanding of the effect of work zone weather-related crashes frequency and severity. In this study, the second Strategic Highway Research Program (SHRP2) Roadway Information Database (RID) were used to compare the characteristics of work zone weather-related crashes and crashes occurred in clear weather conditions at the same locations. The results showed that although there is a reduction in work zone crashes in Washington from 2006 to 2013, Work zone weather-related crashes increased from 14.5% of total crashes occurred in work zones in 2006 to 17.73% in 2013. In this paper, ordered probit model was utilized to gain better understanding about the effect of various factors on different injury severity at work zones during different weather conditions. Lighting conditions, vehicles involved, alcohol involvement, maximum posted speed and two types of crashes (Angle crashes and rear-end crashes) have the most effect on the severity of work zone weather-related crashes. On the other hand, gender, age, land-use, vehicles involved, type of crashes, driving under the influence and road characteristics have the most effect on work zone crashes severity in clear weather conditions.