Design-build projects are becoming more prevalent as agencies seek to speed up projects to leverage resources through growing use of public-private partnerships, accelerated project timelines, and contracting out design work. There is a need, however, to explore differences between design-build processes and traditional design-bid-build processes and to produce additional best practices and guidance for agencies, owners, and stakeholders in design-build projects. This project constitutes the second phase of previous work to develop these resources. The specific objectives of this project are to identify and share best practices and guidance on work zone management, quality assurance, and transportation management plan (TMP) development for design-build projects. This information is packaged within this report as a series of lessons learned, best practices, tools for developing TMPs, and sample checklists. This material is presented in five chapters briefly summarized as follows: “Chapter 2: Lessons Learned and Best Practices in Design-Build Projects” presents bulleted lists of lessons learned and best practices in design-build projects, organized around a variety of pertinent issues and subjects in design-build processes; “Chapter 3: Transportation Management Plan Development Tools for Design-Build Projects” presents development tools for the development of TMPs in general as well as for the development of TMP components including Temporary Traffic Control Plans, Traffic Incident Management Plans, and Public Information and Outreach Plans; “Chapter 4: Quality Assurance Tips for Work Zones in Design-Build Projects” presents a concise, bulleted tip list for managing work zones in design-build projects; “Chapter 5: Quality Assurance Checklists for Work Zones in Design-Build Projects” presents a series of sample inspection checklists to aid design-builders and owners/agencies in conducting quality assurance (QA) for work zones in various phases of design-build projects; and “Chapter 6: Additional Checklists to Support Design-Builders and Owners/Agencies” presents an additional series of sample checklists to support design-builders and owners/agencies in various processes of design-build projects.