A work zone intrusion alert technology is a type of safety system that is used in a roadway work zone to alert field workers and secure time for them to escape when errant vehicles intrude into the work zone. Although such technologies have potential to significantly improve the overall safety of construction work zones, previous studies reported mixed findings, resulting in limited application of intrusion alert technologies. In response, the primary goal of this research study is to scientifically assess the effectiveness of currently available work zone intrusion alert technologies, and to provide recommendations for use of the technologies in future ODOT construction and maintenance work zones. To fulfill this goal, the research gathered information about work zone intrusion alert technologies, gained experiential input and advice from ODOT staff and industry practitioners, and tested technologies under controlled conditions and in active work zones. While sample sizes were limited, the findings from the study indicate that aspects of intrusion alarms via visual, audio, and haptic means can be effective warning mechanisms in a work zone. To improve the potential impacts of these technologies, this report identifies recommended minimum standards for each of the aforementioned means of alert. Implementation of the research results is expected to assist ODOT with enhancing the safety of motorists and workers in construction work zones on high-speed roadways.